Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics
2020-08-10
Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics
本院覽號
28A-941103
公告日期
2020-08-10
智財權狀態
美國臨時案已申請、PCT已申請、台灣(發明)已申請、美國7,919,521放棄維護、美國8,273,788放棄維護
摘要
A novel 5-membered iminocyclitol derivative is found to be a potent and selective inhibitor of the glycoprotein processing α-glucosidase. It has alos been shown as effective further developed into antiviral agent against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus. In addition, it can inhibit human β-hexoaminidase, a new target for development of osteoarthritis therapeutics.
技術優勢
Novel compound Low IC 50 New target for development of osteoarthritis therapeutics
應用範圍
Antivirals and Osteoarthritis Therapeutics
創作人
Chi-Huey Wong, Pi-Hui Liang, Yi-Ling Lin
Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics
